In this article we will discuss about the structure of bacteriophage. Bacteriophage ØX174 belongs to the genus Micro virus of the family Microviridae from the Group II (ssDNA Viruses). The bacteriophage ØX174 was discovered by R.L. Sinsheimer at California Institute of Technology. It is one of the ssDNA phages of E.coli which has been most extensively studied. The phage particles [...]
In this article we will discuss about the life cycle of phage M13. M13 uses the F pilus of E. coli to infect the cell. Protein pill located on the tip of M13 contacts the TolA protein located on the pilus of host cell. This interaction causes a conformational change in pVIlI from 100% alpha-helix to 85% alpha-helix resulting in [...]
In this article we will discuss about the working of immune system in the presence of HIV. Infection is carried out through the spicules present on envelope of HIV which attach to the target cell. The gpl20 has affinity for a specific molecule, the T4 or CD4 molecule exposed on the surface of certain cells i.e. lymphocytes. The lymphocytes secrete [...]