TLRs are transmembrane proteins expressed by cells of the innate immune system, which recognize invading microbes and activate signaling pathways that launch immune and inflammatory responses to destroy the invaders. Mammalian TLRs consist of an extracellular portion containing leucine-rich repeats, a transmembrane region and a cytoplasmic tail, called the TIR (Toll-IL-IR (Interleukin-1-Receptor)) homology domain. Different […]
Toll-Like Receptors (TLR) and Innate Immune System | Human Body | Biology
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