Successful therapy of microbial infections depends upon several factors viz. identification of pathogens and their drug sensitivity, rapid attainment of effective drug concentration at the site of infection, host defenses and maintenance of drug level for adequate period, use of supportive drugs and duration of treatment. The therapeutic concentration of drug at focus of infection is however, based on its [...]
This article provides a note on chloramphenicol. Chloramphenicol is a highly active, broad spectrum antibiotic with excellent pharmacokinetic properties. Source: It is obtained from Actinomyces venezuelae. It is the first antibiotic to be synthesised commercially. Chemistry: It is a derivative of di-chloroacetic acid and contains nitrobenzene moiety. It is a white or grey or yellow fine crystalline powder. It is [...]
Here is a list of nine aminoglycoside antibiotics. 1. Streptomycin: 1. Isolated from streptomyces griseus in 1943. 2. Very soluble in water. 3. Stable compared with penicillin. 4. Pure dry powder remain full potency at room temperature for at least 2 years. 5. Intestinal absorption poor. 6. Used in the treatment of enteritis. 7. Slow absorption from I/M route. 8. [...]