In this article we will discuss about the mechanisms of regulation of transcription in higher eukaryotes. In E. coli, the RNA polymerase holoenzyme (with sigma factor) contains all the information needed to accurately initiate transcription given proper promoter signals (-35 recognition sequence plus -10 Pribnow box). However, RNA polymerase II of eukaryotes, which transcribes most of the protein- encoding nuclear [...]
Get the answer of: Can Eukaryotic Gene Regulated by Hormones ? Most of the hormones in human are either peptide or peptide derivatives in nature or steroid in nature. The peptide hormones do not normally enter cells because of their relatively large size. Their effects appear to be mediated by receptor proteins located in target cell membranes and also by [...]
In this article we will discuss about the regulation of levels of transcription by DNA methylation. In most higher plants and animals, the DNA is often modified after synthesis by the enzymatic conversion of many cytosine bases to 5-methylcytosine bases (Fig. 5.8). The extent of methylation varies from species to species; in mammals, from 2 to 7 percent of the [...]