In this article we will discuss about the study of a complete chromosomes. For karyotype analysis, a sample of peripheral blood is drawn from an individual, the leukocytes separated and cultured for about 3 days. To stimulate growth and cell division phyto-haemaglutinin (PHA) is added. The dividing lymphocytes are arrested at metaphase stage by exposing […]
Study of a Complete Chromosomes | Genetics
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4 Main Types of Chromosomal Anomalies | Genetics
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The following points highlight the four main types of chromosomal anomalies. The types are: 1. Autosomal Anomalies 2. Sex Chromosome Anomalies 3. Chromosomes and Spontaneous Abortions 4. Chromosomes in Disorders with DNA Repair Defects. Type # 1. Autosomal Anomalies: The first known case of a chromosomal anomaly associated with a clinical disorder was described by […]
Genetics of the Haemoglobins | Human Genetics
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In this article we will discuss about the normal and abnormal haemoglobins. I. Normal Haemoglobin: Haemoglobin consists of 4 polypeptide (globin) chains each associated with a single haem group. There are 5-6 types of haemoglobins normally present at different stages of life, from zygote to adulthood. The embryonal haemoglobins (HbE) are heterogeneous and designated Gower-1, […]
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