The most frequent combinations of the X-linked recessive mode of inheritance are as follows: 1. The mother is homozygous and normal (XX); the father is hemizygous and affected (X'Y). (Here X' indicates the chromosome carrying the defective gene and X indicates the normal chromosome). All of the sons of this union will be normal and they will inherit the normal [...]
In this article we will discuss about the dominant and recessive types of autosome-linked genetic diseases. Type # 1. Autosome-Linked Dominant Genetic Diseases: Experimental genetics strictly defines the dominant mode of Inheritance of genetic diseases as the situation in which a single dose of gene is quite sufficient to allow the trait thus governed full expression (Table 11.1). The heterozygote [...]
In this article we will discuss about causes for the oncogenicity of the oncogene. When the oncogene from human bladder carcinoma cells was sequenced, and its sequence was compared with the sequence of the homologous proto-oncogene, its oncogenicity was found to result from a single base pair substitution. That is, a single base pair difference was shown to correlate with [...]