In this article we will discuss about:- 1. Structure of Chloramphenicol 2. Antibiotic Spectrum of Chloramphenicol 3. Mechanism of Action. Structure of Chloramphenicol: Chemically, chloramphenicol is a simple structure (Fig. 45.12) made up of nitrobenzene ring bonded with non-ionic chlorine. It consists of two unusual components—one nitro (-NO2) group and a dichloroacetyl (-COCHCl2) group. The […]
Chloramphenicol: Structure and Mechanism of Action | Antibiotics
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Streptomycin: Discovery, Structure and Mechanism | Antibiotics
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In this article we will discuss about:- 1. Structure of Streptomycin 2. Antibiotic Spectrum of Streptomycin 3. Mechanism of Action 4. Dependence. Structure of Streptomycin: Streptomycin is characterised chemically as an aminoglycoside antibiotic. It consists of three components linked glycosidically (by ether bonds): (i) Streptidine (inositol with two guanido groups), (ii) Streptose (methyl pentose), and […]
Short Notes on Nalidixic Acid | Antibiotics
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Nalidixic acid is credited to be the first quinolone synthesized in laboratory in 1962. Its chemical structure is shown in Fig. 45.16. It is a broad spectrum chemotherapeutic agent and is useful against gram-negative bacteria (causing urinary tract infection) and some gram-positive ones. Nalidixic acid is bactericidal and is effective when administered orally. This antibiotic […]
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