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The upcoming discussion will update you about the differences between Glycolysis and Krebs’ Cycle.
Glycolysis:
1. Site of glycolysis is the cytoplasm.
2. It is a linear pathway of metabolic reactions.
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3. This is first stage of respiration in which glucose is broken down to the level of pyruvate (Pyruvic acid).
4. Glycolysis is common to both aerobic as well as anaerobic respiration.
5. Here a molecule of glucose in degraded into two molecules of an organic substance, pyruvate.
6. It consumes 2ATP molecules for the initial phosphorylation of substrate molecule.
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7. In glycolysis, one molecule of glucose liberates 4 ATP molecules through substrate level phosphorylation.
8. Here the net gain is two molecules of NADH2 and two molecules of ATP for each molecule of glucose broken down.
9. The net gain of energy is equal to 8 ATP.
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10. No carbon dioxide is evolved in glycolysis.
11. It is not connected with oxidative phosphorylation.
12. Oxygen is not required for glycolysis.
Krebs’ Cycle:
1. It operates inside mitochondria.
2. It is a cyclic pathway.
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3. It is second stage of respiration. Where an active acetyl group is broken down completely.
4. Krebs’ Cycle operates only in aerobic respiration.
5. Here the pyruvate is completely degraded to inorganic substances (CO2 + H2O).
6. ATP is not consumed during Krebs’ cycle.
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7. In Krebs’s cycle, two acetyl residues liberate two ATP or GTP molecules through substrate level phosphorylation.
8. Here six molecules of NADH2 and 2 molecules of FADH2 for each two molecules of Acetyl CoA oxidized, are produced.
9. The net gain of energy is equal to 24 molecules of ATP six molecules of ATP can be produced from 2NADH2 formed during dehydrogenation of two pyruvates.
10. Carbon dioxide is evolved during Krebs’ Cycle.
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11. Krebs’ Cycle is connected with oxidative phosphorylation.
12. Krebs’ Cycle consumes oxygen as terminal oxidant.
